b'Zimeta dipyrone) with additional ingredients addedNUTRITION(dipyrone injection) to maintain masking during administration. 500mg/mL injectionTable 1: Adverse Reactions Reported For intravenous use in horsesDuring the Field Study with ZimetaNon-steroidal anti-inflammatory drug (NSAID) Zimeta TM Control CAUTION: Federal law (U.S.A.) restricts this(dipyroneProduct drug to use by or on the order of a licensedAdverse Reaction injection) (N=31)veterinarian.(N=107)Before using this product, pleaseElevated Serum5 (5%) 5 (16%) Staying Legalconsult the product insert, aSorbitol Dehydro-summary of which follows: genase (SDH) Before giving your performance horse a Indication: Zimeta (dipyrone injection) isHypoalbuminemia 3 (3%) 1 (3%)indicated for the control of pyrexia in horses.Gastric Ulcers 2 (2%) 0 (0%) calming supplement, confirm that its legal DosageandAdministration:AlwaysHyperemic Mucosa1 (1%) 0 (0%) for use in competition. A variety of governing provide the Client Information Sheet withRight Dorsal Colon bodies oversees breeds and disciplines, and theprescription.AdministerZimetabyProlonged1 (1%) 0 (0%)intravenous injection, once or twice daily,Activated Partialeach group constantly updates its lists of at 12 hour intervals, for up to three days,Thromboplastinbanned and approved substances. Violation at a dosage of 30 mg/kg (13.6 mg/lb). SeeTime (APTT)product insert for complete dosingElevated Creatinine 1 (1%) 0 (0%) of these policies can result in penalties and administration information. Injection Site1 (1%) 0 (0%) ranging from a warning to being banned Contraindications:HorseswithReaction hypersensitivitytodipyroneshouldnotAnorexia 1 (1%) 1 (3%) from competition. It is the rider and trainers ISTOCK.COMreceive Zimeta. Due to the prolongation ofresponsibility to ensure compliance, so prothrombin time (PT) and associated clinicalSee Product Insert for complete signs of coagulopathy, dipyrone should not beAdverse Reaction information. check rule updates often, especially prior to given more frequently than every 12 hours. Information for Owners or Personcompetition. Warnings: For use in horses only. Do not useTreating Horse: A Client Information Sheet in horses intended for human consumption.should be provided to the person treatingAdditionally, some supplement components can cause false positives. I remember sev-Do not use in any food producing animals,thehorse.Treatmentadministratorsanderal years ago, when I working as part of a drug testing team, competitors were concerned including lactating dairy animals. caretakers should be aware of the potential for adverse reactions and the clinical signsabout peppermints causing false positives. The common starlight mints werent the Human Warnings: Care should be takenassociated with NSAID intolerance. Adverse to ensure that dipyrone is not accidentallyreactions may include colic, diarrhea, andissue; a more natural form of peppermint treat was. Thus, its important to remember that injected into humans as studies have indicateddecreased appetite. Serious adverse reactionsjust because a product is natural, it isnt necessarily legal. Also, just because a product thatdipyronecancauseagranulocytosis can occur without warning and, in some in humans. situations, result in death. Clients should bedoesnt test does not mean its legal, especially if association rules state that calming and Not for use in humans. Keep this and all drugsadvised to discontinue NSAID therapy andperformance-enhancing agents are not allowed.out of reach of children. In case of accidentalcontact their veterinarian immediately if any exposure, contact a physician immediately.signs of intolerance are observed. Two major governing bodies over multiple disciplines are the United States Equestrian DirectcontactwiththeskinshouldbeEffectiveness:TheeffectivenessphaseFederation (USEF) and Fdration questre Internationale (FEI). You can find current rules avoided. If contact occurs, the skin should bewasarandomized,masked,controlled, washed immediately with soap and water.multicenter, field study conducted to evaluatefor legal medications at usef.org/forms-pubs/2Zp2C_YKs4s/drugs-medications-guidelines As with all injectable drugs causing profoundtheeffectivenessofZimeta(dipyroneand inside.fei.org/fei/cleansport/ad-h/prohibited-list. Several breed organizations have physiologicaleffects,routineprecautionsinjection) administered intravenously at 30 should be employed by practitioners whenmg/kg bodyweight in horses over one year ofspecifications, as well. For example, the American Quarter Horse Association (AQHA) lists handling and using loaded syringes to prevent accidental self-injection. age with naturally occurring fevers. Enrolledregulations for breed shows at aqha.com/-/get-the-2020-aqha-rulebook. horses had a rectal temperature 102.0F. Precautions:HorsesshouldundergoaA horse was considered a treatment successAgain, the onus for compliance falls on the owner/rider and trainer. What can make this thorough history and physical examinationif 6 hours following a single dose of studycomplicated is that regulations can differ between organizations, and occasionally there are before initiation of any NSAID therapy. drug administration the rectal temperature As a class, NSAIDs may be associated withdecreased2.0Ffromhour0,ortheexceptions for horses that fall into specific categories. In addition, some organizations have platelet dysfunction and coagulopathy. Zimetatemperature decreased to normal (101.0F). very broad statements such as the use of calming agents and sedatives is prohibited, and has been shown to cause prolongation ofOne hundred and thirty-eight horses received coagulation parameters in horses.Therefore,treatment(104Zimetaand34controlit is up to the individual to interpret.Janice L. Holland, PhD, PAShorsesonZimetashouldbemonitored product) and 137 horses (103 Zimeta and forclinicalsignsofcoagulopathy.34 control product) were included in the Caution should be used in horses at risk statisticalanalysisforeffectiveness.At6 for hemorrhage. hours post-treatment, the success rate was As a class, NSAIDs may be associated with74.8% (77/103) of Zimeta treated horses and gastrointestinal, renal, and hepatic toxicity.20.6% (7/34) of control horses. The resultsanti- inflammatory and antidiarrhealboth for people and horse, she says. Sensitivity to drug-associated adverse eventsof the field study demonstrate that Zimeta administered at 30 mg/kg intravenously waspotential added benefits for nervousAnd from a horse welfare standpoint, varies with the individual patient. Considereffective for the control of pyrexia 6 hours stopping therapy if adverse reactions, suchfollowing treatment administration.horses. However, many equine organi- only known effective and safe treatments asprolongedinappetenceorabnormal feces, could be attributed to gastrointestinalRefer to the Product Insert forzations ban the use of sedatives, evenshould be used. toxicity. Patients at greatest risk for adversecomplete Effectiveness information.natural ones such as chamomile. Also, first try any supplement at home events are those that are dehydrated, onStorage Information: Store at Controlled diuretictherapy,orthosewithexistingRoom Temperature 20 and 25C (68 andon a normal day to evaluate how it works renal,cardiovascular,and/orhepatic dysfunction.Concurrentadministrationof77F); with excursions permitted between 15Take-Home Message on your horse before using it in a stress-potentiallynephrotoxicdrugsshouldbeand 30C (59 and 86F). Protect from light.Multi-dosevial.Usewithin30daysof Horse owners should completelyful situation on the farm or away from carefullyapproachedoravoided.Sincefirst puncture.manyNSAIDspossessthepotentialtoevaluate what might be causing a horseshome. Try only one product at a time to produce gastrointestinal ulcerations and/orHow Supplied: Zimeta is available gastrointestinal perforation, concomitant useas a 500mg/mL solution in a 100mL,undesired behavior before trying a calm- determine if it works and to ensure it of Zimeta with other anti-inflammatory drugs,multi-dose vial. ing supplement. First eliminate healthproduces no side effects.hsuch as NSAIDs or corticosteroids, should beApproved by FDA under NADA # avoided. The influence of concomitant drugs141-513 NDC 86078-245-01 conditions, training issues, and dietary that may inhibit the metabolism of ZimetaManufactured for: imbalances as causes. If you do decide toREFERENCEShas not been evaluated. Drug compatibilityKindred Biosciences, Inc.should be monitored in patients requiringtry a calming supplement, make sure its1. Davis BP, Engle TE, Ranson JI, and Grandin T. 2017.adjunctive therapy.1555 Bayshore Hwy, Suite 200, Preliminary evaluation on the effectiveness of varying The safe use of Zimeta in horses less thanBurlingame, CA 94010one thats backed by research showing itdoses of supplemental tryptophan as a calmative in three years of age, horses used for breeding,To report adverse reactions callworks, is safe, and is legal for use in yourhorses. Applied Animal Behaviour Science, 188:34-41.or in pregnant or lactating mares has not beenKindred Biosciences, Inc. atevaluated.Considerappropriatewashout1-888-608-2542. breed and/or discipline competitions.2. McDonnell SM, Miller J, and Vaala W. 2013. Calmingtimes when switching from one NSAID toZimeta is a trademark ofKindredMcDonnell also recommends onlybenefit of short-term alpha-casozepine supplementa-another NSAID or a corticosteroid. Biosciences, Inc. tion during acclimation to domestic environment and AdverseReactions:Adversereactions 2019 Kindred Biosciences, Inc. All rightsusing those supplements with ingredi- basic ground training of adult semi-feral ponies. Journal reported in a controlled field study of 138reserved. ents that have shown positive results inof Equine Veterinary Science, 33(2):101-106.horses of various breeds, ranging in age from 1 to 32 years of age, treated withRev. 11-2019 blinded, peer-reviewed research.3. Singh N, Bhalla M, De Jager P, and Gilca M. 2011. AnZimeta (n=107) or control product (n=31)KB50002_ZIV-BS-1Putting trust in an unproven or inef- overview on Ashwagandha: a rasayana (rejuvenator) of are summarized in Table 1. The controlAyurveda. African Journal of Traditional, Complementary product was a vehicle control (solution minusfective treatment can increase safety risksand Alternative Medicines, 8(5 Suppl):208-213.36April 2020The Horse|TheHorse.com'