Researchers Digging Deeper into African Horse Sickness

As the threat of African horse sickness in parts of Europe grows, scientists are turning to a genetic level of understanding and fighting the disease.
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As the threat of African horse sickness (AHS) in parts of Europe grows, scientists are turning to a genetic level of understanding and fighting the disease.

African horse sickness is a fatal viral disease spread by Culicoides–tiny, blood-sucking insects–that can affect horses, mules, and donkeys, as well as dogs and camels. Horses are most susceptible to AHS, with a 75-90% mortality rate. A vaccine is available, but no effective treatment methods exist for infected horses. For survivors, recovery is slow.

Researchers at the London School of Hygiene and Tropical Medicine, in England, have recovered the AHS-causing virus from RNA (a special kind of genetic material involved in gene expression) they developed in their own laboratory. With that synthetic material, the researchers hope to use what they call “reverse genetics” to comprehend the virus at the molecular level—how it reproduces and spreads, how it interacts with the infected animal’s cells, and how it causes disease. But perhaps more importantly, their work can contribute to vaccine development, said Polly Roy, MSc, PhD, FMedSci, professor of virology and supervising researcher on the project.

“This kind of vaccine is very different in its mechanism of action compared to a traditional rabies or flu vaccine, because those are based on recombinant (or those developed in a laboratory) proteins, not on the actual virus,” Roy said

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Passionate about horses and science from the time she was riding her first Shetland Pony in Texas, Christa Lesté-Lasserre writes about scientific research that contributes to a better understanding of all equids. After undergrad studies in science, journalism, and literature, she received a master’s degree in creative writing. Now based in France, she aims to present the most fascinating aspect of equine science: the story it creates. Follow Lesté-Lasserre on Twitter @christalestelas.

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