New Resistance Genes: What’s the Threat to Horses?

A recently discovered resistance gene in bacteria has focused attention on emerging multidrug resistance.
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Recent identification of the mcr-1 resistance gene in bacteria from humans and animals has focused attention on the emerging epidemic of multidrug resistance.

Multidrug resistant Gram-negative bacteria, particularly those of the Enterobacteriaceae family (e.g. E. coli, Klebsiella, Enterobacter), are not new, as serial waves of resistance mediated by a wide range of genes have been encountered. Yet, emergence of mcr-1 is of concern because it confers resistance to colistin, an antimicrobial that is the only option for some highly drug-resistant infections. Concern has been expressed that mcr-1 has ushered in the era of pan-resistant infections—infections where there are no antimicrobial options.

Equine medicine has not escaped the challenges posed by resistant bacteria, including multidrug resistant Enterobacteriaceae. In recent years, there have been various reports of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae in horse. These are resistant to penicillins and most cephalosporins, and typically also have acquired resistance to various other antimicrobials, limiting treatment options. Susceptibility to only aminoglycosides (e.g. amikacin) and carbapenems (e.g. meropenem) is a common pattern. These ESBL-producing bacteria have been identified in horses in multiple countries, both in healthy colonized horses and horses with clinical infections. While carbapenem use is very limited in horses, carbapenemase-producing Enterobacteriaceae (CPE) and Acinetobacter, which are resistant to penicillins, cephalosporins, and carbapenems, and usually a range of other antimicrobials, have been found in limited numbers in horses. With the common co-occurrence of resistance to other drug classes, infections by bacteria such as these approach the ‘pan resistance,’ from a practical standpoint, considering limitations in antimicrobials that can be used in horses. Of additional note is the fact that ESBLs found in horses are often the same types that are found in people (e.g. CTX-M-15), highlighting both the potential for zoonotic transmission and the likelihood that some equine infections are human in origin.

What does identification of mcr-1 mean to the equine industry and equine veterinarians? The likelihood of encountering a horse infected with a bacterium possessing mcr-1 is exceedingly low. However, if bacteria harboring genes such as these increase in humans, food animals, and the environment, equine infections are probably inevitable. Yet, while attracting less attention, the endemic level of resistance to cephalosporins, fluoroquinolones, and aminoglycosides is likely of greater relevance in horses because of their increasing incidence and the limited treatment options

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