Bone Marrow-Derived Stem Cells Aid Bone Healing

Bone marrow-derived mesenchymal stem cells (BMDMSCs) can be genetically modified in culture and subsequently used in live horses to enhance healing of bone defects, according to Colorado State University (CSU) researchers.

“BMDMSCs are ‘flexible’ cells that have the capacity to become one of a variety of connective tissue cell types, including bone cells (osteoblasts)

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Bone marrow-derived mesenchymal stem cells (BMDMSCs) can be genetically modified in culture and subsequently used in live horses to enhance healing of bone defects, according to Colorado State University (CSU) researchers.

"BMDMSCs are 'flexible' cells that have the capacity to become one of a variety of connective tissue cell types, including bone cells (osteoblasts). BMDMSCs can be aspirated from a horse, expanded (grown) in cell culture, then used in the same horse to enhance bone healing," relayed Laurie Goodrich, DVM, PhD, Dipl. ACVS, an assistant professor in equine lameness and surgery at CSU.

Specifically, BMDMSCs may be genetically modified to produce growth factors called bone morphogenic proteins (BMPs) that increase the rate of bone formation and maturation. The ultimate goal is to place these cells in a bone defect to lead to an increase in mechanical strength of bone.

Preliminary studies have found that BMP-2 and BMP-7 could be particularly useful in bone healing

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Written by:

Stacey Oke, MSc, DVM, is a practicing veterinarian and freelance medical writer and editor. She is interested in both large and small animals, as well as complementary and alternative medicine. Since 2005, she’s worked as a research consultant for nutritional supplement companies, assisted physicians and veterinarians in publishing research articles and textbooks, and written for a number of educational magazines and websites.

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