Cushing's Disease

Article

Autumn Challenges for Cushing's Diagnosis, Management

September 27, 2008

Owners of older horses that exhibit any of the classic signs of Cushing's during the fall months work with their veterinarians to determine whether they should test or treat horses until diagnoses can be confirmed.... Read More

Article

Diagnosing Insulin Resistance: Q&A with Researchers

August 28, 2008

Over the past few years researchers have described a strong association between insulin resistance and laminitis in equines. They are working now on defining standard testing protocols and interpretations to identify horses at highest risk for... Read More

Article

Laminitis, PPID: The Science of Seasons Behind Them

July 20, 2008

Research groups reported their findings of the impact of seasonal variations for pituitary glad dysfunction.... Read More

Video

Metabolic Disorders

July 10, 2008

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Article

Cushing's, Parkinson's Link? Oklahoma State Researcher Receives Grant for Study

December 10, 2007

Dianne McFarlane, DVM, PhD, Dipl. ACVIM, Dipl. ABVP, is an assistant professor with the Oklahoma State University (OSU) Center for Veterinary Health Sciences. McFarlane recently received a grant from the National Institutes of Health (NIH) to... Read More

Article

Wedgewood Introduces Peppermint- and Alfalfa-Flavored Pergolide

December 04, 2007

Wedgewood Pharmacy has introduced peppermint- and alfalfa-flavored pergolide for horses in its Gourmeds dosage form. Gourmeds are chewable, naturally flavored tablets that are easy to administer.

Pergolide mesylate, a drug used to treat... Read More

Article

Carb Testing Program for Horse Feed and Hay

October 30, 2007

When it comes to horses, what does "low carb" mean? Lower than what? "There are several analytical procedures that measure sugar, and each one measures a slightly different fraction," said Kathryn Watts, BS, owner of Rocky Mountain Research & Consult... Read More

Article

Healthy Horses: Endocrine System Function and Flaws

September 25, 2007

Horses suffer from few endocrine disorders compared to humans and companion animals; however, they're not totally off the hook, explained Emily Graves, VMD, MS, Dipl. ACVIM, of Michigan State University, to horse owners in attendance at the... Read More

Article

What Causes Pituitary Pars Intermedia Dysfunction?

July 23, 2007

The lack of dopamine is critical, as the activity of the pars intermedia is normally inhibited (controlled) by dopamine. Without dopamine, the pars intermedia produces much more hormone than it should, causing the clinical signs of PPID.... Read More

Article

Treating Pituitary Pars Intermedia Dysfunction (or Cushing's Disease)

July 19, 2007

Medication options for PPID include pergolide, cyproheptadine, trilostane, and chasteberry extract. One disadvantage is that no treatment is currently FDA-approved for PPID in horses.... Read More

Article

Understanding Pituitary Pars Intermedia Dysfunction (a.k.a. Cushing's Disease)

July 18, 2007

Pituitary pars intermedia dysfunction--PPID, or Cushing's disease--is the most common disease of horses and ponies 15 years of age or older. Although it's not fully understood yet, researchers are learning more about how to treat and prevent it.... Read More

Article

Diagnosing Pituitary Pars Intermedia Dysfunction

July 17, 2007

Unfortunately, no perfect PPID test (one that is 100% accurate with a single-sample test) yet exists. At the 2006 AAEP Convention, Harold Schott, DVM, PhD, Dipl. ACVIM, professor of large animal clinical sciences at Michigan State University,... Read More

Article

Challenges of Cushing's Disease Diagnosis and Treatment

July 02, 2007

We know Cushing's disease (or pituitary pars intermedia dysfunction—PPID—as it's more scientifically called), simply put, is an "old-horse disease" that results in metabolism disturbances and an abnormally heavy hair coat. But when it comes to... Read More

Article

Pergolide: FDA to Allow Compounding From Bulk

May 11, 2007

The Food and Drug Administration's (FDA) Center for Veterinary Medicine announced on May 11 it will allow bulk pergolide to be used in compounding pergolide for use in horses.

Pergolide mesylate, a drug commonly used to treat pituitar... Read More

Article

Pergolide Availability: No FDA Announcement, Supplies Running Low

May 04, 2007

More than a month after pergolide mesylate, a drug commonly used to treat pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease, was withdrawn for human use, the FDA has yet to make an announcement on whether... Read More

Article

Pergolide: Veterinarians, Horse Owners Fighting for Availability

April 17, 2007

Pergolide mesylate, a drug commonly used to treat pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease, has been withdrawn for human use. The FDA made this announcement March 29. Since that time, horse owners and... Read More

Article

Equine Cushing's Drug Pergolide to be Withdrawn for Human Use

April 04, 2007

The FDA has announced pergolide is to be voluntarily withdrawn for human use. Pergolide is commonly used for horses with pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease.

According to the FDA announcement... Read More

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Obese Horses

March 23, 2007

Experts at the 2006 AAEP Convention discussed equine obesity in depth.... Read More

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Horse Management and Care

March 23, 2007

Management topics at the 2006 AAEP Convention included numerous tips for keeping older horses healthy.... Read More

Article

AAEP Convention 2006: Obese Horses

March 01, 2007

Adipobiology (The Study of Fat in the Body): An Emerging Field... Read More

Article

Nutrition to Go

March 01, 2007

A group of veterinarians gathered at the Land O' Lakes Purina Mills headquarters in St. Louis, Mo., last fall to participate in discussions on subjects that ranged from Cushing's disease to proper nutrition for horses young and old. Nicholas Frank,... Read More

Article

Equine Metabolic Syndrome Versus Cushing's Syndrome

February 19, 2007

Fresh from the AAEP Annual Convention, here's an update on what we know about these two disorders and how to manage them:

Equine metabolic syndrome typically affects horses aged 8 to 18-years-old. Pony breeds, domesticated Spanish... Read More

Article

Dopamine and Its Evil Twin Ergovaline

February 01, 2007

In the horse, the hormone dopamine exerts a number of effects through its actions on the pituitary gland. Both dopamine and ergovaline, a dopaminergic agonist (a drug that stimulates dopamine receptors), can significantly impact the mare's... Read More

Article

Cushing's Disease in Horses

March 01, 2006

It's spring, yet your aging equine has failed to shed his long, shaggy, winter coat. Furthermore, he's developed a saggy belly coupled with loss of muscle over his croup and rump. He's gulping down far more water than he used to, and his stall i... Read More

Article

AAEP Convention 2004 Wrap-Up: Horseman's Day

March 03, 2005

Horseman's Day, as part of the annual American Association of Equine Practitioners Convention, just keeps getting better and better. And attendance is strong no matter where the convention is held. Most recently, the locale was Denver, Colo., on... Read More