Medicinal Control of Tying-Up

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Dantrolene sodium (Dantrium) is used to control exertional rhabdomyolysis (ER, also called tying-up) in horses. Diagnosis of ER is typically confirmed by a finding of increased serum creatine kinase (CK), which is often greater than 1,000 IU at its peak (normal CK levels are around 200 IU). While Dantrium has been in use for about 20 years, there is little published data regarding its efficac

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