Tying-up is the most common muscle problem in horses. This syndrome is also called azoturia, set fast, paralytic myoglobinuria, and chronic exertional rhabdomyolysis (ER). HYPP (hyperkalemic periodic paralysis) in Quarter Horses is a different problem. Tying-up is not a single disease, but a collection of clinical signs with various causes. Several of these causes for tying-up have already

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