Endurance and Endotoxemia

Endotoxemia in horses is usually associated with severe infections, inflammation, and colic. Endotoxin from intestinal bacteria activates release of inflammatory mediators such as thromboxane B2 (TxB2), tumor necrosis factor-alpha (TNF-alpha), prostaglandin F1-alpha (PGF1-alpha), and interleukin-6 (IL-6). These mediators produce malaise, fever, dehydration, cardiovascular collapse, organ

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