On Dec. 18, 2000, a vaccine to prevent EPM was approved by the USDA. As of Jan. 25, a total of 43 states had approved the use of the EPM vaccine under USDA conditional licensure. The vaccine must be used under the supervision of a veterinarian. It requires a two-dose initial series at least two weeks apart, followed by an annual booster. The label says it should be used in healthy horses

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