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Endotoxemia

Articles ( = TheHorse.com members only )	Date Posted
Experimental Endotoxemia Drug Performs Poorly in Horse Study Pirfenidone, a unique experimental drug with anti-fibrotic and anti-inflammatory properties, afforded no apparent therapeutic benefit in horses with experimentally-induced endotoxemia, leaving Cal Davis researchers rather disappointed. "Previous studies led us to believe that pirfenidone would minimize the effects of circulating lipopolysaccharide ... Read full story	8/23/2009
ACVIM Conference Highlights Among the hot topics this year were nutritional supplements, infectious disease, and metabolism problems. What do nutritional supplements, infectious diseases, and snake bites have in common? All were considered "hot topics" in equine health at the 2008 American College of Veterinary Internal Medicine (ACVIM) Forum held at the Henry B. Gonzalez Convention ... Read full story	10/1/2008
Experimental Drug Research Provides Promising Results Endotoxemia. Septic shock. Intestinal ischemia. What do all these ailments have in common? Based on recent studies, some researchers think an investigational drug called pirfenidone might be a treatment option for all three. "Pirfenidone, which is currently approved for oral use in humans, is a unique drug with anti-inflammatory and anti-fibrotic ... Read full story	7/24/2008
Endurance and Endotoxemia Endotoxemia in horses is usually associated with severe infections, inflammation, and colic. Endotoxin from intestinal bacteria activates release of inflammatory mediators such as thromboxane B2 (TxB2), tumor necrosis factor-alpha (TNF-alpha), prostaglandin F1-alpha (PGF1-alpha), and interleukin-6 (IL-6). These mediators produce malaise, fever, dehydration, ... Read full story	7/1/2004
New Treatment for Endotoxemia Michelle Henry Barton, DVM, PhD, of the University of Georgia, recently completed a project on treating endotoxemia with polymyxin B (PMB), an alternative to endotoxin antibody products. The drug PMB kills many Gram-negative bacteria and also binds endotoxin, preventing interaction of endotoxin with white blood cells (WBC) as do endotoxin antibody ... Read full story	3/1/2003
AAEP Convention 2001: Gastrointestinal Disease Milne Lecture Hundreds of veterinarians waited patiently in line in San Diego, Calif., on the afternoon of Nov. 26--and not at the airport. They were waiting in the AAEP trade show to purchase a copy of "The Glass Horse," a digital, three-dimensional electronic horse model developed by James N. Moore, DVM, PhD, and two of his colleagues at the University ... Read full story	2/1/2002
"Glass Horse" Unveiled at Veterinary Convention Hundreds of veterinarians waited patiently in line in San Diego, Calif., on the afternoon of Nov. 26—and not at the airport. They were waiting in the American Association of Equine Practitioners convention trade show to purchase a copy of “The Glass Horse,” a digital, three-dimensional electronic horse model developed by James N. Moore, DVM, PhD, and ... Read full story	1/3/2002
AAEP 1995 Convention Roundup A total of 2,351 equine veterinarians--a record attendance--descended on Lexington for the 41st annual American Association of Equine Practitioners convention. Committee business dominated the day on Dec. 2, with 21 of the association's 40 committees meeting to discuss topics of concern and offer recommendations to the board of directors for action. ... Read full story	10/4/2001