Cushing's Disease


Geldings Sought for Cushing's Study at Auburn

April 14, 2009

Researchers at Auburn University need horses to participate in a study that will examine the use of chasteberry (vitex agnus castus) supplements in horses with Cushing's disease.

This study, which is being conducted throug... Read More


Internal Medicine Table Topic

March 17, 2009

Table topics from the 2008 AAEP Convention included internal medicine. ... Read More


Stability and Efficacy of Compounded Pergolide Examined

February 21, 2009

Researchers have recently cautioned horse owners currently treating horses diagnosed with pituitary pars intermedia dysfunction (PPID, or equine Cushing's syndrome) that the compounded form of the drug pergolide mesylate can become... Read More


Glucosamine in a Cushing's Horse?

December 01, 2008

Q: As soon as my 20-year-old gelding was diagnosed with equine Cushing's disease, I eliminated glucosamine from his diet. However, he appears to have become gradually and increasingly stiff and short-strided without it. I really think that it helped ... Read More


Cushing's Horses Sought for Pergolide Study

November 25, 2008

Elanco Animal Health (a division of Eli Lilly and Company), in collaboration with Michigan State University, Oklahoma State University, and Louisiana State University, is seeking horses with equine Cushing's disease, also known as pituitary pars... Read More


Autumn Challenges for Cushing's Diagnosis, Management

September 27, 2008

Owners of older horses that exhibit any of the classic signs of Cushing's during the fall months work with their veterinarians to determine whether they should test or treat horses until diagnoses can be confirmed.... Read More


Diagnosing Insulin Resistance: Q&A with Researchers

August 28, 2008

Over the past few years researchers have described a strong association between insulin resistance and laminitis in equines. They are working now on defining standard testing protocols and interpretations to identify horses at highest risk for... Read More


Laminitis, PPID: The Science of Seasons Behind Them

July 20, 2008

Research groups reported their findings of the impact of seasonal variations for pituitary glad dysfunction.... Read More


Metabolic Disorders

July 10, 2008

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Cushing's, Parkinson's Link? Oklahoma State Researcher Receives Grant for Study

December 10, 2007

Dianne McFarlane, DVM, PhD, Dipl. ACVIM, Dipl. ABVP, is an assistant professor with the Oklahoma State University (OSU) Center for Veterinary Health Sciences. McFarlane recently received a grant from the National Institutes of Health (NIH) to... Read More


Wedgewood Introduces Peppermint- and Alfalfa-Flavored Pergolide

December 04, 2007

Wedgewood Pharmacy has introduced peppermint- and alfalfa-flavored pergolide for horses in its Gourmeds dosage form. Gourmeds are chewable, naturally flavored tablets that are easy to administer.

Pergolide mesylate, a drug used to treat... Read More


Carb Testing Program for Horse Feed and Hay

October 30, 2007

When it comes to horses, what does "low carb" mean? Lower than what? "There are several analytical procedures that measure sugar, and each one measures a slightly different fraction," said Kathryn Watts, BS, owner of Rocky Mountain Research & Consult... Read More


Healthy Horses: Endocrine System Function and Flaws

September 25, 2007

Horses suffer from few endocrine disorders compared to humans and companion animals; however, they're not totally off the hook, explained Emily Graves, VMD, MS, Dipl. ACVIM, of Michigan State University, to horse owners in attendance at the... Read More


What Causes Pituitary Pars Intermedia Dysfunction?

July 23, 2007

The lack of dopamine is critical, as the activity of the pars intermedia is normally inhibited (controlled) by dopamine. Without dopamine, the pars intermedia produces much more hormone than it should, causing the clinical signs of PPID.... Read More


Treating Pituitary Pars Intermedia Dysfunction (or Cushing's Disease)

July 19, 2007

Medication options for PPID include pergolide, cyproheptadine, trilostane, and chasteberry extract. One disadvantage is that no treatment is currently FDA-approved for PPID in horses.... Read More


Understanding Pituitary Pars Intermedia Dysfunction (a.k.a. Cushing's Disease)

July 18, 2007

Pituitary pars intermedia dysfunction--PPID, or Cushing's disease--is the most common disease of horses and ponies 15 years of age or older. Although it's not fully understood yet, researchers are learning more about how to treat and prevent it.... Read More


Diagnosing Pituitary Pars Intermedia Dysfunction

July 17, 2007

Unfortunately, no perfect PPID test (one that is 100% accurate with a single-sample test) yet exists. At the 2006 AAEP Convention, Harold Schott, DVM, PhD, Dipl. ACVIM, professor of large animal clinical sciences at Michigan State University,... Read More


Challenges of Cushing's Disease Diagnosis and Treatment

July 02, 2007

We know Cushing's disease (or pituitary pars intermedia dysfunction—PPID—as it's more scientifically called), simply put, is an "old-horse disease" that results in metabolism disturbances and an abnormally heavy hair coat. But when it comes to... Read More


Pergolide: FDA to Allow Compounding From Bulk

May 11, 2007

The Food and Drug Administration's (FDA) Center for Veterinary Medicine announced on May 11 it will allow bulk pergolide to be used in compounding pergolide for use in horses.

Pergolide mesylate, a drug commonly used to treat pituitar... Read More


Pergolide Availability: No FDA Announcement, Supplies Running Low

May 04, 2007

More than a month after pergolide mesylate, a drug commonly used to treat pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease, was withdrawn for human use, the FDA has yet to make an announcement on whether... Read More


Pergolide: Veterinarians, Horse Owners Fighting for Availability

April 17, 2007

Pergolide mesylate, a drug commonly used to treat pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease, has been withdrawn for human use. The FDA made this announcement March 29. Since that time, horse owners and... Read More


Equine Cushing's Drug Pergolide to be Withdrawn for Human Use

April 04, 2007

The FDA has announced pergolide is to be voluntarily withdrawn for human use. Pergolide is commonly used for horses with pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease.

According to the FDA announcement... Read More


Obese Horses

March 23, 2007

Experts at the 2006 AAEP Convention discussed equine obesity in depth.... Read More


Horse Management and Care

March 23, 2007

Management topics at the 2006 AAEP Convention included numerous tips for keeping older horses healthy.... Read More


AAEP Convention 2006: Obese Horses

March 01, 2007

Adipobiology (The Study of Fat in the Body): An Emerging Field... Read More